br P Agostinis Spatiotemporal autophagic degradation of oxid
P. Agostinis, Spatiotemporal autophagic degradation of oxidatively damaged or-ganelles after photodynamic stress is amplified by mitochondrial reactive oxygen species, Autophagy 8 (9) (2012) 1312–1324.
M.H. Abdel Kader, H. Stepp, ABCG2-mediated suppression of chlorin e6 accumu-lation and photodynamic therapy eﬃciency in glioblastoma cell lines can be re-versed by KO143, J. Photochem. Photobiol. B 178 (2018) 182–191.
 G.A. Barron, H. Moseley, J.A. Woods, Diﬀerential sensitivity in cell lines to pho-todynamic therapy in combination with ABCG2 inhibition, J. Photochem. Photobiol. B 126 (2013) 87–96.  J.W. Jonker, M. Buitelaar, E. Wagenaar, M.A. Van Der Valk, G.L. Scheﬀer, R.J. Scheper, T. Plosch, F. Kuipers, R.P. Elferink, H. Rosing, J.H. Beijnen, A.H. Schinkel, The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria, Proc. Natl. Acad. Sci.
 M.D. Perloﬀ, L.L. von Moltke, E. Stormer, R.I. Shader, D.J. Greenblatt, Saint John’s wort: an in vitro analysis of P-glycoprotein induction due to extended exposure, Br.
V. Sackova, J. Hofmanova, A. Kozubik, P. Fedorocko, Drug eﬄux transporters, MRP1 and BCRP, aﬀect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells, Photochem. Photobiol. Sci. 8 (12) (2009)
J. Remsik, K. Soucek, A. Kozubik, P. Fedorocko, Hypericin aﬀects cancer side po-pulations via competitive inhibition of BCRP, Biomed. Pharmacother. 99 (2018) 511–522.  Z. Hollo, L. Homolya, T. Hegedus, B. Sarkadi, Transport properties of the multidrug
R. Jendželovský et al.
J. Hofmanova, A. Kozubik, P. Fedorocko, Modulation of hypericin photodynamic therapy by pretreatment with 12 various inhibitors of arachidonic Tofacitinib metabolism in colon adenocarcinoma HT-29 cells, Photochem. Photobiol. 83 (5) (2007) 1174–1185.
P. Fedorocko, Conjunction of glutathione level, NAD(P)H/FAD redox status and hypericin content as a potential factor aﬀecting colon cancer cell resistance to photodynamic therapy with hypericin, Photodiagn. Photodyn. Ther. 10 (4) (2013) 470–483. Biomedicine & Pharmacotherapy 109 (2019) 2173–2181
P. Fedorocko, J. Imrich, P. Kristian, J. Kasparkova, V. Brabec, M. Kozurkova, 3,6-bis (3-alkylguanidino)acridines as DNA-intercalating antitumor agents, Eur. J. Med. Chem. 57 (2012) 283–295.  M. Semelakova, R. Jendzelovsky, P. Fedorocko, Drug membrane transporters and CYP3A4 are aﬀected by hypericin, hyperforin or aristoforin in colon adenocarci-noma cells, Biomed. Pharmacother. 81 (2016) 38–47.  M. Semelakova, J. Mikes, R. Jendzelovsky, P. Fedorocko, The pro-apoptotic and anti-invasive eﬀects of hypericin-mediated photodynamic therapy are enhanced by hyperforin or aristoforin in HT-29 colon adenocarcinoma cells, J. Photochem. Photobiol. B 117 (2012) 115–125.  J. Prochazkova, L. Kubala, H. Kotasova, I. Gudernova, Z. Sramkova, M. Pekarova,
J. Hofmanova, A. Kozubik, P. Fedorocko, Lower sensitivity of FHC fetal colon epithelial cells to photodynamic therapy compared to HT-29 colon adenocarcinoma cells despite higher intracellular accumulation of hypericin, Photochem. Photobiol. Sci. 10 (4) (2011) 626–632.
Breast Cancer Screening Awareness and Practices Among Women Attending Primary Health Care Centers in the Ghail Bawazir District of Yemen
Amen Bawazir,1,2 Najla Bashateh,3 Hoda Jradi,1 Ahlam Bin Breik3
This cross-sectional study aimed to assess breast cancer screening awareness and practices among women attending primary health care centers in the Ghail-Bawazir district of Yemen. A significant association between marital status, level of education, working status, and level of knowledge and breast screening practice was reported. Health care providers play a very limited role in providing awareness to their patients.
Introduction: Women with from breast cancer often present to health care facilities with an advanced stage of dis-ease. This study assessed the breast cancer screening awareness and practices among women presenting to primary health care centers in the Ghail-Bawazir district of Yemen. Material and Methods: A cross-sectional descriptive study was carried out from November 1, 2016 through January 31, 2017. A total of 317 women who attended primary health care centers in the Ghail-Bawazir district during the study period were randomly selected for inclusion in the study. Data analysis was carried out using the Statistical Package for the Social Sciences (SPSS) Version 20. Descriptive statistics and c2 analysis were used to present the frequency distributions and associations that existed in the data. The data was displayed in tables and graphs. Results: Very limited information on breast cancer was obtained from health care providers (14%). Around one-half of the respondents had satisfactory levels of breast cancer knowledge and awareness, whereas 30.3% were practicing self-breast examination, and only 1.6% had ever been exposed to a mammogram test. A significant association between marital status, level of education, working status, and level of knowledge and breast screening practice was reported (P ¼ .01). By regression analysis, age and limited level of knowledge on self-breast examination were found determinant (P < .015) in factors associated with the use of clinical breast examination. Conclusion: The study reveals the satisfactory knowledge of women about breast cancer along with inadequate awareness of breast cancer screening and screening practices.